Ayesha was born in a Pakistani family on 27 September 1981. Her family basically hails from Lahore, Pakistan. Her father is of Punjabi descent and her mother is of Kashmiri descent.
Ayesha was raised in Abu Dhabi and Canada. She adapted into the Pakistani culture just as her career in Pakistan's entertainment industry began.
Ayesha can be credited for playing some extremely well-loved characters on the Pakistani television. She has appeared in several Pakistani television serials. She is not only the top model but leading drama actress of Pakistan TV industry. Her notable dramas include Mane na ye dil and Kafir. One of her most popular acts has been the character of Sajjal in Mehndi, a 2003 drama serial which was produced by Ever new Pictures and directed by Javed Fazil, where she played opposite Humayun Saeed. Ayesha Khan has earned herself reputation in the industry as a skilled actress over the years.